Human genome databases at the crossroads

Genome editing at the crossroads of delivery, specificity, and fidelity.

Genome editing (GE) entails the modification of specific genomic sequences in living cells for the purpose of determining, changing, or expanding their function(s). Typically, GE occurs after delivering sequence-specific designer nucleases (e.g., ZFNs, TALENs, and CRISPR/Cas9) and donor DNA constructs into target cells. These designer nucleases can generate gene knockouts or gene knock-ins when...

Editorial. At the crossroads.

Colombia at the Crossroads

ove rv i ew The In s ti tute for the Stu dy of Di p l om acy hosted the spring session of the Sch l e s i n ger Work i n g Group on the topic of s tra tegic su rprise in Co l ombi a . Af ter a pre s en t a ti on on four po ten tial scen a rios that may face Co l om bia (see next page ) , S ch l e s i n ger Working Group core mem bers and Co l om bia specialists ex a m i n ed the key factors dri...

Immunology at the crossroads

tell us stories that live in our minds long after we read their words. After 20 years of training some 200 graduate students, I can report some progress in convincing editors that properly trained scientists can do the job of reporting on science for general readers. However—and this is a big however— editors still insist that these scientists must, no matter what their qualification in science...

Scribble at the crossroads

Although proteins involved in determining apical-basal cell polarity have been directly linked to tumorigenesis, their precise roles in this process remain unclear. A recent report in BMC Biology clarifies the signaling pathways that control cell polarity, proliferation and apoptosis downstream of the tumor suppressor and apical-basal polarity determinant Scribble.